Journal of Neonatal Nursing
Volume 17, Issue 6 , Pages 197-202 , December 2011

The effects of therapeutic hypothermia on term infants with neonatal asphyxial encephalopathy

References 

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  2. Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. The New England Journal of Medicine. 2009;36(14):1349–1358
  3. Barks JDE. Current controversies in hypothermic neuroprotection. Seminars in Fetal and Neonatal Medicine. 2008;13:30–34
  4. Barnet AL, Guzzeta A, Mercuri E, et al. Can the Griffiths scales predict neuromotor and perceptual – motor impairment in term infants with neonatal encephalopathy?. Archives of Disease in Childhood. 2004;89:637–643
  5. British Association of Perinatal Medicine., 2010. Position Statement on Therapeutic Cooling for Neonatal Encephalopathy.
  6. Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. British Medical Journal. 2010;340:c363–c369
  7. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365(9460):663–670
  8. Haines A, Jones R. Implementing findings of research. British Medical Journal. 1994;308:1488
  9. Kirpalani H, Banks J, Thorlund K, Guyatt G. Cooling for neonatal hypoxic ishemic encephalopathy: do we have the answer?. Pediatrics. 2007;120:1126–1130
  10. Laptook A, Tyson J, Shankaran S, et al. Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes. Pediatrics. 2008;122(3):491–499
  11. NICE IPG374: Therapeutic hypothermia for intracorporeal temperature monitoring for hypoxic perinatal brain injury: guidance. issued May 2010 http://www.nice.org.uk/nicemedia/live/11315/48809/48809.pdf.
  12. Palisano R, Rosenbaum P, Walter S, et al. Development and reliability of a system to classify gross motor function in children with cerebral palsy. Developmental Medicine and Child Neurology. 1997;39:214–223
  13. Public Health Resource Unit., 2006. Critical Appraisal Skills Programme (CASP): 10 Questions to Help You Make Sense of Randomised Controlled Trials.
  14. Shankaran S, Laptook AR, Ehrenkranz RA, et al., National Institute of Child Health and Human Development Neonatal Research Network  Whole body hypothermia for neonates with hypoxic – ischemic encephalopathy. The New England Journal of Medicine. 2005;353(15):1574–1584
  15. Simbruner G, Mittal RA, Rohlmann F, Muche R, neo.nEURO.network Trial Participants . Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics. 2010;126(4):e771–e778www.pediatrics.org/cgi/content/full/126/4/e771Available at:
  16. Thoresen M, Satas S, Loberg EM, et al. Twenty-four hours of mild hypothermia in unsedatednewborn pigs starting after a severe global hypoxic-ischemic insult is not neuroprotective. Pediatric Research. 2001;50(3):405–411
  17. Wyatt JS, Robertson NJ. Time for a cool head – neuroprotection becomes a reality. Early Human Development. 2005;81:5–11

PII: S1355-1841(11)00144-X

doi: 10.1016/j.jnn.2011.09.002

Journal of Neonatal Nursing
Volume 17, Issue 6 , Pages 197-202 , December 2011